Membrane-active aminophosphonates.

Xenobiotic exposure may induce cell membrane injury which would affect cellular structures and function. This study examined the influence of new aminophosphonates, synthesized for agrochemical application, on biological and model membranes properties. The aminophosphonates differed in the substituents on their carbon, nitrogen and phosphorus atoms. Measurements were made of the stability of planar lipid membranes (BLM), the hemolysis of erythrocytes (RBC) and the fluidity of ghost erythrocyte membranes. We have already shown that these models are convenient to study the interaction of agents with the lipid phase of biological membranes [1, 2].